• Assessment of Dynamic Changes in Stressed Volume and Venous Return during Hyperdynamic Septic Shock 

      Chalkias A., Laou E., Papagiannakis N., Spyropoulos V., Kouskouni E., Theodoraki K., Xanthos T. (2022)
      The present work investigated the dynamic changes in stressed volume (Vs) and other determinants of venous return using a porcine model of hyperdynamic septic shock. Septicemia was induced in 10 anesthetized swine, and ...
    • Combination of exercise training and dopamine agonists in patients with RLS on dialysis: A randomized, double-blind placebo-controlled study 

      Giannaki C.D., Sakkas G.K., Karatzaferi C., Maridaki M.D., Koutedakis Y., Hadjigeorgiou G.M., Stefanidis I. (2015)
      Both exercise training and treatment with dopamine agonists (DA) have been used with success for the amelioration of uremic restless legs syndrome (RLS) symptoms. However, no data are available combining those two approaches. ...
    • Disturbances of acquired immunity in hemodialysis patients 

      Eleftheriadis, T.; Antoniadi, G.; Liakopoulos, V.; Kartsios, C.; Stefanidis, I. (2007)
      Acquired immunity disturbances in hemodialysis (HD) patients are many and diverse. They are caused by uremia per se, the HD procedure, chronic renal failure complications, and therapeutic interventions for their treatment. ...
    • Epidemiology and importance of renal dysfunction in heart failure patients 

      Giamouzis, G.; Kalogeropoulos, A. P.; Butler, J.; Karayannis, G.; Georgiopoulou, V. V.; Skoularigis, J.; Triposkiadis, F. (2013)
      Renal dysfunction (RD) is a frequent comorbid condition and a major determinant of outcomes in patients with heart failure (HF). It is likely that the etiology of RD in patients with HF is much more complex than we first ...
    • EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI): Study protocol for a multicentre, observational trial 

      Weiss R., Saadat-Gilani K., Kerschke L., Wempe C., Meersch M., Zarbock A., Makhloufi H., Cherak A., Ghanem L.L., Gouaglia Z., Guadouri D.N., Hama F.N., Kara M., Saadi O., Sakhraoui R., Bourou F., Cherifi A., Sadaoui R.G., Ouyahia A., Ouahab I., Bouaoud S., Abdoun M., Tidjane A., Tabeti B., Boudjenan-Serradj N., Rivera C.J.P., Cabrer P., Corso J., García J.P., Idarraga S., Montoya C., Figueroa R., Aldana E., Torrado M.A., Peng K., Ma Z.-M., Yang Y.-F., Zhu Y.-J., Sklienka P., Frelich M., Jarkulis V., Sevcik P., Vodicka V., Elbahnasawy M.G., Elsalhawy S., Motawea S., Othman Z., Sahma M., Nafea A.M., Ahmed N., Attia D.A., Emara M.M., Bonna M.M., Gabr M.A., Tarbay A.I., Abdehaleem I.A., Mohamed E.E., Eldeeb A.M., Abbas A.M., Magdy J.A., Hamed Z.H., Osman H.M.E., Abbas M.S., Joannes-Boyau O., Barraud N., Berthelot C., Camus T., Dahmi A., Defaye M., Derville S., El-Boustani Y., Deloge E., Jacob H., Monziols S., Priem F., Robin J.-J., Legros V., Floch T., Muccio S., Geneve C., Legouge M.L., Mauny S.T., Mfam W., Pascot L., Aveline C., Chartier M., Duteurtre B., Gautier J.F., Cousin A.L., Vautier P., Nadaud J., Begel N., Chekirine C.-A., Derlon V., Grein E., Lehair M.-A., Magazzeni L., Magazzeni P., Potter C., Roth C., Voivret F., Rimmelé T., Cerro V., Suria S., Elmawieh J., Stoclin A., Cirenei C., Andrieu G., Couloumy S., Falcone J., Fajardy M., Gagneuil A., Girardet E., Mazereeuw A., Ponsonnard S., Egreteau P.-Y., Bertel M., Bocher S., Carn V., Guen L.L., Loup G.L., Lefevre M., Ichai C., Diop A., Jean-Michel V., Devlieger S., Duthoit J., El Kadiri M., Léger M., Cassisa V., Lasocki S., Masson C., Rineau E., Verrier P., Coquerel A., Montravers P., Atchade E., Rochon C.-E., Delerue C., Quentin V., Latry V., Queixalos N., Cottenceau V., Braun T., Bouzoubaa S., Christ B., Geiger A., Gomille J., Kieffer V., Mangeant S., Prochilo C., Schmitt C., Skwirba S., Grand H., Boury F., Mayeur N., Pasquie M., Garçon P., Bruckert V., Arnould V., Bonciu M., Chapelle T., Facchino L., Fagot-Gandet F., Iachim A., Mannu E., Perus O., Plattier R., Rozier R., Pradel G., Boudinaud M., Hausermann M.-H., Nguyen M.H., Ramorasata A., Barreau A., Boivin A.-H., Ravry C., Mottard N., Beuvelot J., Bossion F.P., Desebbe O., Zarbock A., Dörr C., von Groote T.C., Küllmar M., Massoth C., Meersch M., Saadat-Gilani K., Weiss R., Wempe C., Ziemann S., Grüßer L., Kowark A., Wittig P., Brandenburger T., Dimski T., Döhmen N., Huthmann L., Kaierle D., Pelletier C., Schleß M., Hohn A., Cleophas S., Haunhorst S., Jansen M., Schmitt A., Soisch J., Sturm K., Rosenberger P., Bendig A., Flohr L., Häberle H., Hofmann P., Kuhle J., Leser N.M., Pfister K., Prohaska S., Sennholz F., Stetz L., Weber K., Stehr S., Klaus S., Sadlo M., Boschin M., Sengelhoff C., Göbel U.M., Haaker J.G., Göttker C.-K., Gründel M., Heringlake M., Baumgärtel R., Berggren A., Gülzow M., Muras L., Paarmann H., Thal S., Bentley A., El-Masri D., Sebastiani A., Arnaoutoglou E., Ntalouka M., Stratigopoulou P., Analytis A., Mavrommatis E., Tzimas P., Karakosta A., Pantazi D., Dimakopoulou A., Dimitropoulou K., Ioannidis O., Jalaawiy H., Anwar A., Hashim H.T., Aldawoody H.I.R., Cortegiani A., Catalisano G., Ingoglia G., Ippolito M., De Rosa S., Cattin L., Bianchin A., Barone M., Paternoster G., Cutuli S.L., Russo A., Sollazzi L., Cascarano L., Antonelli M., Aceto P., Romanò B., Spadaro S., Tripodi V.F., Rossi M., Scappatura R., Vadalà M.C., Fiume D., Strano M.T., Oddo G., Santorsola C., Hussain B.A., Alnaser A.R., Ghassan A.H., Hasanein K., Theab M., Shin S., Jung S., Lee K., Jung S.M., Baek J., Elhadi M.K., Aldressi W.W.O., Abuzeid I., Albaraesi M., Aldressi S., Khalel W., Abdulwahed E., Abujrad A.A.A., Almaghrabi A., Alteleeb M., Alshareea E.A.A., Biala M.I., Deeknah A., Gheddim D.A., Ghmagh R., Ikhrays N.S.A.A., Sinan M., Soula E., Bahroun S.G., Derwish K., Mohamed A.M., Younes E.S., Al Islam Benjouira R., Aliwa M., Altashani N.A., Alteb M.O., Msherghi A., Alagelli F., Albarouni S., Albishti A., Aljamal S., Alsori M., Ekhuja T., Elzwai S., Ghula M., Mustafa T., Tuwaib A., Zriba H., Agilla H.M., Rafanomezantsoa T.A., Podesta A.M.C., Bonnici D.M., Pirotta T., López G.A.G., Mijovska M.M., Davitkovska T., Gavrilovska A., Lukikj S., Vesova M., Zafirova D., Amro S., Hajjaj B.N.F., Alkhazendar M., Barakat Y., Elejla S.A., Elhissi A., Khader A., Salem A., de Freitas Regufe R., de Oliveira Eloy A.F., Perdigão L.M.N.C., Grigoriev E., Ivkin A., Kornelyuk R., Yaroustovsky M., Abramyan M., Komardina E., Lesteva N., Aybazova M., Kumykova E., Lesina S., Rybakov G., Shestov A., Barmou A.A.A., Ahmed B.L.A., Eliyas A.M., Emadeldin Y., Kaserer A., Castellucci C., Rössler J., Akbas S., Petrun A.M., Gregorcic I., Sok V., Cicak R., Bárcena E., Guisado A., Wi I., Melchor J.R., Becerra-Bolaños Á., Cabrera-Doreste S., Domínguez-Arbelo A., Delgado-Alonso M.C., Muiño-Palomar V., Rodríguez-Pérez A., Estévez J.M., Munoz M.B.C., Matas J.M., Palao S.P., Quirós M.D.M., Teslev A.C., Argilaga M., Campos M., Bainac A., Batalla A., Alvarez M.G., Giné M., Herránz G., Hinojal I., Ejea M.L., de la Rosa Ruiz N., Abasolo M.G., Acuna C.R.H., Zaranton I.I., Mendigurenmurua A., Sanz M.J.M., de la Fuente E.O., Vaquero M.P.P., Iglesias A.S., Mieres A.U., Urrestizala A.U., Ferreira L., Lobato F., Sevilla M.A., Erazo A., Miró P., Sabaté S., Vernetta D., Perez A.A., Pagola M.A., Paulis B.C., del Val Peciña E., Odriozola A.G., Aizpurua A.L., Piquer O.P., Garcia P.P., Rezola P.O., Lopez A.O., de la Calle Gil I., Casado R.N., Adamove P., Domenge R.B., Blasco F.M.B., Villamizar A.A.R., Llaneras M.A.P., García-Sánchez J.I., Téllez L.F., Zamorano S.G., Herreros N.G., Esteve A.R., Rodríguez P.M., Trigo I.G., Alcaraz A., Jiménez A.L., Rubio I., García N., Callejas R., Toha A.M.C., Claros E., Cobeta P., Crespo P., Dorado T., Elías E., Felices J., Gil D., Gómez M., Mané N., Martín M., Martínez A., Pereira L., Samaranch A.B.N., Serrano A., Tiscar C., VillaHoz J., Menéndez P.G., Cardona E., Conesa A., Estepa V., Galán P., Espí L.L., Aldeán Y.L., Manrique S., Ariza V.M., Villa L.V., Suliman E.S.M.A., Hamid H., Ibrahim A.M., Saeed M.M., Mukadder O.S., Altun D., Canbolat N., Dinçer M.B., Seyhan T.Ö., Yildirim S.A., Iyigün M., Yapici D., Özdemir L., Sagun A., Boztug N., Cetintas Y., Dinc B., Gündüz E., Ünlügenç H., Tunay D.L., Karakaya D., Dost B., Komurcu O., Akcil E.F., Dilmen Ö.K., Tunali Y., Ok G., Alsina E.T., Hakli Ö., Polat C., Turgut N., Kizilcik N., Köner Ö., Sen Ö., Aydin N., Basaran B., Bingul E.S., Gürkan Y., Darcin K., Ugur S., Saracoglu K.T., Demir A., Aysegül Ö., Balci E., Girgin B., Guler A., Karadeniz Ü., Özaslan N., Hülya Y.Ö., Ozcan N., Postaci A., Sahap M., Salman N., Sagir Ö., Atik B., Bicakcioglu M., Demir H.F., Fatih U., Kocaoglu N., Toprak H.I., Aslan D.D., Colak Y.Z., Ozcan M.S., Yilmaz M., Karaca U., Sahin S.H., Karka Ö.E., Senoglu G.D., Karadag S.E., Alkis N., Baytas V., Akdogan A., Besir A., Erturk E., Kutanis D., Saylan S., Tugcugil E., Ayvat P., Günaydin B., Büyükgebiz B.M., Boran O.F., Calisir F., Orak Y., Balkan B.K., Büyükcoban S., Gökel E., Günenc S.F., Özbilgin S., Göre S., Akesen S., Cansabuncu S., Momot N., Panchenko A., Pittet J.-F., Rutledge K., the EPIS-AKI Investigators (2021)
      Introduction More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. ...
    • Epidemiology, impact, and treatment options of restless legs syndrome in end-stage renal disease patients: An evidence-based review 

      Giannaki, C. D.; Hadjigeorgiou, G. M.; Karatzaferi, C.; Pantzaris, M. C.; Stefanidis, I.; Sakkas, G. K. (2014)
      Restless legs syndrome (RLS) (or Willis-Ekbom disease) is a neurological disorder with high prevalence among the end-stage renal disease population. This is one of the most predominant types of secondary RLS, and it is ...
    • Heparin-coated extracorporeal circulation systems in heart surgery 

      Tagarakis, G. I.; Tsilimingas, N. B. (2009)
      Despite the progress accomplished in the field of off-pump heart surgery, the vast majority of cardiac operations are still performed with the use of extracorporeal circulation, otherwise known as "heart-lung machine." ...
    • Hypertension in Dialysis Patients: Diagnostic Approaches and Evaluation of Epidemiology 

      Georgianos P.I., Vaios V., Sgouropoulou V., Eleftheriadis T., Tsalikakis D.G., Liakopoulos V. (2022)
      Whereas hypertension is an established cardiovascular risk factor in the general population, the contribution of increased blood pressure (BP) to the huge burden of cardiovascular morbidity and mortality in patients receiving ...
    • ICU-Associated Gram-Negative Bloodstream Infection: Risk Factors Affecting the Outcome Following the Emergence of Colistin-Resistant Isolates in a Regional Greek Hospital 

      Karvouniaris M., Poulakou G., Tsiakos K., Chatzimichail M., Papamichalis P., Katsiaflaka A., Oikonomou K., Katsioulis A., Palli E., Komnos A. (2022)
      Intensive care unit patients may present infections by difficult-to-treat-resistant Gram-negative microorganisms. Colistin resurfaced as a last resort antibiotic for the treatment of multidrug-resistant Gram-negative ...
    • Inflammation, Hyperglycemia, and Adverse Outcomes in Individuals With Diabetes Mellitus Hospitalized for COVID-19 

      Vasbinder A., Anderson E., Shadid H., Berlin H., Pan M., Azam T.U., Khaleel I., Padalia K., Meloche C., O’hayer P., Michaud E., Catalan T., Feroze R., Blakely P., Launius C., Huang Y., Zhao L., Ang L., Mikhael M., Mizokami-Stout K., Pennathur S., Kretzler M., Loosen S.H., Chalkias A., Tacke F., Giamarellos-Bourboulis E.J., Reiser J., Eugen-Olsen J., Feldman E.L., Pop-Busui R., Hayek S.S. (2022)
      OBJECTIVE Diabetes mellitus (DM) is a major risk factor for severe coronavirus disease 2019 (COVID-19) for reasons that are unclear. RESEARCH DESIGN AND METHODS We leveraged the International Study of Inflammation in ...
    • Molecular Mechanisms of Peritoneal Membrane Pathophysiology 

      Zarogiannis S.G., Schmitt C.P. (2022)
      [No abstract available]
    • Mortality of intubated patients with COVID-19 during first and subsequent waves: a meta-analysis involving 363,660 patients from 43 countries 

      Xourgia E., Katsaros D.E., Xixi N.A., Tsolaki V., Routsi C., Zakynthinos S.G., Kotanidou A., Siempos I.I. (2022)
      Background: We attempted to investigate the change in mortality of intubated patients with coronavirus disease (COVID-19) from first to subsequent waves across several countries. Methods: We pre-registered our meta-analysis ...
    • Oxidative Stress and Acute Kidney Injury in Critical Illness: Pathophysiologic Mechanisms - Biomarkers - Interventions, and Future Perspectives 

      Pavlakou P., Liakopoulos V., Eleftheriadis T., Mitsis M., Dounousi E. (2017)
      Acute kidney injury (AKI) is a multifactorial entity that occurs in a variety of clinical settings. Although AKI is not a usual reason for intensive care unit (ICU) admission, it often complicates critically ill patients' ...
    • Oxidative stress in the critically ill patients: Pathophysiology and potential interventions 

      Makris D., Mertens P.R., Dounousi E., Giamouzis G., Nseir S. (2018)
      [No abstract available]
    • Pathogenesis and management of intradialytic hypertension 

      Dousdampanis, P.; Trigka, K.; Giannopoulos, A.; Fourtounas, C. (2014)
      Hypertension is common in chronic kidney disease patients especially in those undergoing hemodialysis (HD). Usually, blood pressure falls after the HD session but in some patients a paradoxical increase has been observed ...
    • Polysomnographic evidence of sleep apnoea disorders in lean and overweight haemodialysis patients 

      Sakkas, G. K.; Karatzaferi, C.; Liakopoulos, V.; Maridaki, M. D.; Lavdas, E.; Giannaki, C. D.; Gourgoulianis, K. I.; Stefanidis, I. (2007)
      Background - Sleep apnoea disorders affect a large proportion of patients with renal failure. However, it is unknown whether body composition and visceral adiposity predispose haernodialysis patients to sleep apnoea ...
    • Serum levels of adipokine retinol-binding protein-4 in relation to renal function 

      Papavasileiou, V.; Liakopoulos, V.; Sakkas, G. K.; Hadjigeorgiou, G. M.; Koukoulis, G.; Stefanidis, I. (2008)
    • Soluble urokinase receptor (SuPAR) in COVID-19-Related AKI 

      Azam T.U., Shadid H.R., Blakely P., O'Hayer P., Berlin H., Pan M., Zhao P., Zhao L., Pennathur S., Pop-Busui R., Altintas I., Tingleff J., Stauning M.A., Andersen O., Adami M.-E., Solomonidi N., Tsilika M., Tober-Lau P., Arnaoutoglou E., Keitel V., Tacke F., Chalkias A., Loosen S.H., Giamarellos-Bourboulis E.J., Eugen-Olsen J., Reiser J., Hayek S.S., Hayek S.S., Blakely P., Berlin H., Azam T.U., Shadid H., Pan M., O'Hayer P., Meloche C., Feroze R., Padalia K.J., Anderson E., Perry D., Bitar A., Kaakati R., Zhao L., Zhao P., Eugen-Olsen J., Altintas I., Tingleff J., Stauning M., Houlind M.B., Lindstrøm M.B., Andersen O., Gamst-Jensen H., Rasmussen L.J.H., Rasmussen C., Nehlin J.O., Kallemose T., Parvaiz I., Adami M.-E., Solomonidi N., Tsilika M., Saridaki M., Lekakis V., Loosen S., Luedde T., Keitel V., Arnaoutoglou E., Pantazopoulos I., Laou E., Kolonia K., Skoulakis A., Tacke F., Tober-Lau P., Mohr R., Kurth F., Sander L.E., Jochum C., International Study of Inflammation in COVID-19 (2020)
      Background AKI commonly occurs in patients with coronavirus disease 2019 (COVID-19). Its pathogenesis is poorly understood. The urokinase receptor system is a key regulator of the intersection between inflammation, immunity, ...
    • Steroids in caRdiac Surgery (SIRS) trial: Acute kidney injury substudy protocol of an international randomised controlled trial 

      Garg, A. X.; Vincent, J.; Cuerden, M.; Parikh, C.; Devereaux, P. J.; Teoh, K.; Yusuf, S.; Hildebrand, A.; Lamy, A.; Zuo, Y.; Sessler, D. I.; Shah, P.; Abbasi, S. H.; Quantz, M.; Yared, J. P.; Noiseux, N.; Tagarakis, G.; Rochon, A.; Pogue, J.; Walsh, M.; Chan, M. T. V.; Lamontagne, F.; Salehiomran, A.; Whitlock, R. (2014)
      Introduction: Steroids In caRdiac Surgery trial (SIRS) is a large international randomised controlled trial of methylprednisolone or placebo in patients undergoing cardiac surgery with the use of a cardiopulmonary bypass ...
    • Thrombolysis for massive pulmonary embolism in a patient with hemorrhagic shock 

      Papanikolaou J., Spathoulas K., Makris D., Zakynthinos E. (2016)
      [No abstract available]